This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

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Epithelial cell rests of Malassez

Epitheliaal cases of trauma, where the ERM are damaged, leading to necrosis, mediators that promote osteoclasia may not be present in the required concentration, which, as a result, may lead to alveolodental ankylosis. LuxRalf Erber European journal of cell biology Unlike bone cells, cementoblasts do not have receptors for remodelling mediators, requiring the beginning of a cascade of events that causes the pH to normalize. Report based on literature review. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.

Epithelial-mesenchy-mal transition-derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells. Showing of 52 references. This role is contrary to the events resulting epitheliap the induced orthodontic tooth movement.

ERM incidence decreased with increasing age. Alveolodental ankylosis is characterized by the absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption. Epithelial cell rests of Malassez: The results showed that the ERM were present in all 31 specimens analyzed regardless of agebut the incidence decreased with increasing age.

The epithelial cell rests of Malassez ERM are formed by persisting fragments of epithelial sheath Hertwig shaeth that participates in the tooth root development. From their potential in the context of maintaining periodontal insertion through the release of inflammatory mediator structures, proteins and growth factors, the ERM were identified as key figures in maintaining homeostasis, assisting in the maintenance of space in the periodontal ligament, cementum repair and regeneration processes and collagen renewal.

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An ultrastructural evaluation of the relationship between epithelial rests of Malassez and orthodontic root resorption and repair in man. Reeve and Wentz 16 determined the frequency fo epithelial rests in patients aged years, classifying different ERM types and locations on the periodontal ligament. Epidermal growth factor restx by the ERM is directly implicated in osteoclastogenesis and eoithelial bone resorp-tion through the inhibition of osteoprotegerin OPGa well-established decoy receptor for RANKL.

The prevalence, morphology, and distribution of epithelial rests in the human periodontal ligament. Loe and Waerhaug 17 were the first to suggest a compatible function for ERM, having described the spatial distribution of these structures around the tooth root. The regeneration of periodontal tissue occurs through assistance in the malxssez of cells that suffered some sort of damage.

Tooth development Epithelial cells. The latter also promote release of bone matrix malaasez, BMP-2, osteopontin, osteoprotegerin and sialoprotein, proteins that aid in the repair and periodontal regeneration phase, aside from contributing to the repair of cementum itself. The synthesis of collagen as well as changes in the matrix of the periodontal ligament contribute to the bone remodelling process, which induces orthodontic forces 57 Open in a separate window.

Some rests become calcified in the periodontal ligament cementicles. Epidermal growth factor in liposomes may enhance osteoclast recruitment during tooth movement in rats. His depth of knowledge on biophysics and laser treatments was simply outstanding. Macrophage-colony stimulating factor M-CSF and several transcription factors are required for the final transformation of haematopoietic stem cells to osteoclasts.


Uber die bedeutung des epithels im periodontalen raum menschlicher und tierischer zahne. Organization and quantification of the collagen ot in bone formation during orthodontic tooth movement. Stem Cell and Dev ; 21 This result suggests the participation of ERM in the regeneration and repair of cementum.

Epithelial rests’ function in replantation is splinting necessary in replantation?

To understand the rational basis of regenerative procedures, a better understanding of the events associated with the formation of periodontal components will help to establish reliable strategies for clinical practice.

Endocrinol ; 1: By using this site, you agree to the Terms of Use and Privacy Policy. Find articles by Epituelial Normando.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Evidence malssez a role of odontogenic epithelium in maintaining the periodontal space. Due to the numerous physiological and regenerative functions that ERM perform within the periodontal ligament, the authors suggest that the current nomenclature of epithelial cell “rests” rexts be replaced by the term epithelial “network” in order to emphasize the central role epitehlial these cells play in the homeostasis of the tooth supporting apparatus.

The bone morphogenetic proteins, especially BMP-2, as well as bone matrix proteins, act in regulating osteogenesis, with an initial rise in the dental follicle. Doubell infers that lasers enable new dental treatments and operating methods, as well as complementing and supporting existing therapeutic dental methods.

Wallace JA, Vergona K. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling.

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