Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. To acquire additional. Mandible / maxilla – Benign tumors / tumor-like conditions: adenomatoid odontogenic tumor.

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Critical evaluation of the radiological and clinical features of adenomatoid odontogenic tumour. However, an AOT often appears to envelop the crown as well as the root, unlike the dentigerous cyst which does not envelop roots.

Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation

Int J Oral Maxillofac Surg ; Pindborg H, Kramar IR. Natl J Maxillofac Surg ; 3: Epigenetic regulation of matrix metalloproteinase expression in ameloblastoma. Adenomatood Center for Biotechnology InformationU.

Case report and review of the literature. Clinicopathological and immunohistochemical study of 39 cases of adenomatoid odontogenic tumour: The adenomatoid odontogenic tumour AOT: The follicular type of ameloblastomas grow and usually form multicystic nodules, resulting in multilocular tumor masses with frequent recurrence compared to the other types of ameloblastomas. The differential diagnosis between ameloblastomas and AOTs is essential. The current WHO classification of odontogenic tumors defines AOT as odontogneic composed of odontogenic epithelium in a variety of histoarchitectural yumors, embedded in mature connective tissue stroma, and characterized by slow but progressive growth.


The lesion is usually unilocular and radiolucent.

It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological, and pathohistological diagnostic procedures, such as immunohistochemical analysis. J Korean Med Sci ; Ameloblastic carcinoma of maxilla. The histology of the biopsy tissue and surgically-removed specimens reveal characteristic features resembling squamous cell carcinoma, basal cell carcinoma, acenomatoid benign follicles of ameloblastoma.

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Basal cell ameloblastoma is also a very rare variant of ameloblastoma resembling basaloid squamous cell carcinoma but possessing the odontofenic features of conventional ameloblastoma. A well-demarcated radiolucent lesion associated with the crown of impacted teeth like in this case ruled out the apical cyst, calcifying odontogenic cyst, odontogenic keratocyst, and central giant cell granuloma [ 101114 ]. Well circumscribed, central proliferation of ductlike epithelium surrounding small foci of calcification Epithelium may have rosettes, trabecular or cribriform patterns Columnar type cells with basal nuclei and clear cytoplasm may resemble pre-ameloblasts Eosinophilic fibrillar material is present between tumor cells and within adrnomatoid structures Rarely melanin deposition.

It is sometimes misdiagnosed as a cyst. There are three variants of AOT-follicular, extrafollicular, and peripheral. Intraoral examination Figure 2 b revealed a solitary smooth circumscribed swelling of 1. The tumors were composed of conventional ameloblastomas Histopathological confirmation of the lesion AOT Click here to odontovenic.

Adenomatoid odontogenic tumor, an uncommon tumor

Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor. Adamantinoma of tibia with predominant features of fibrous dysplasia: Author information Copyright and License information Adenomatoud. The tumor cells resemble the cells seen in ameloblastomas but exhibit cytologic atypia Fig. The introduction of the name “AOT” has resulted in simpler and fruitful surgical management like enucleation and curettage with no reports of recurrence.


The overall incidence rate of craniopharyngiomas is approximately 1. The overexpression of p53 and murine double minute 2 MDM2 are associated with the pathogenesis and oncogenesis of ameloblastomas.

Discussion AOT usually occurs within the tooth bearing areas of jaws and often found in association with impacted teeth. Therefore, fumors type of ameloblastoma requires different forms of treatment. AOT occurs mainly in the second decade of life, and is uncommon tuomrs patients older than 30 years of age.

The histopathologic examination confirmed the diagnosis of a follicular AOT type. The unilocular radiolucency is well demarcated with smooth cortical border. Subscribe to Table of Contents Alerts. Eur Arch Otorhinolaryngol ; The recurrence rate is as low as 0.

Rom J Morphol Embryol ; Therefore, AOTs exhibit less aggressive biological behavior and increased cytodifferentiation and apoptosis than ameloblastomas. This website is intended for pathologists odontogeenic laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

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