Identification. Asteriscus graveolens (Forssk.) Less. [family ASTERACEAE ] ( stored under name); Verified by Not on Sheet, Buphthalmum odorum Schousb. Familia: Asteraceae Subfamilia: Asteroideae Tribus: Inuleae Subtribus: Inulinae Genus: Asteriscus Species: Asteriscus graveolens. In the present study the phytochemical composition and biological activities of the aerial part extracts of Asteriscus graveolens against pathogenic bacteria and.

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The CAM is a complete tissue containing arteries, veins and capillaries, and is technically easy to study. According to other embodiments, the compositions and methods of the present invention employs the complete polar solvent extract derived form A. Any topical formulation as is known in the art can adteriscus used according to the teachings of the present invention.

Cell viability assay was conducted as described in Example 2 hereinabove with the control medium being H 2 O. They are also called polynuclear aromatic hydrocarbons. The cosmetic compositions of the invention may comprise additional acceptable cosmetic agents as known in the art. The experiments showed that extract fraction of Asteriscus graveolens exhibits marked protective effect against cigarette smoke intoxication.

According to some embodiments, the composition is formulated in a form selected from the group consisting of grqveolens solution, cream, lotion, water in oil emulsion, oil in water emulsion, microemulsion, nanoemulsion, gel, serum and milk. According to certain embodiments, the extract or the fraction thereof is essentially devoid of essential oils.

The wrinkles volume was reduced by 9. Non-limiting examples of preservatives include benzoic acid, its salts and esters, sorbic acid and its salts, parabens and their salts, triclosan, imidazolidinyl urea, phenoxyethanol, DMDM hydantoin, diazolidinyl urea and chlorphenesin. According to additional aspect, the present invention provides a composition comprising a polar solvent extract derived from Asteriscus plant or a fraction thereof in an amount effective in protecting a tissue comprising epithelial cells from the deleterious effect of at least one pollutant, further comprising a cosmetically, pharmaceutically or dermatologically acceptable diluents, excipient or carrier.


These have been shown to lead to transepidermal water loss, degeneration of connective tissue in the skin and an increase in MMPs metalloproteinases -enzymes which break down connective skin tissue Jorgensen L N K xsteriscus al. Effect of Various Concentrations of A. You are viewing our newest and freshest images for your search. The extracts and compositions of the invention are highly useful in preventing a damage caused to tissues comprising epithelial cells by exposure to various graveolns, particularly chemical substances including chemicals found in smoke e.

Self assessment of improvement after 28 days of treatment was higher in subjects treated with the compound of the invention as compared to placebo. Normal human epidermal keratinocytes NHEK were cultured in asterisus medium for 24 hours.

According to certain embodiments, the additive is selected from the group consisting of: Cigarette smoke contains over 4, chemical compounds of which about 60 have been designated as carcinogenic. The mixture was heated for 0. Examples of such compounds are aliphatic hydrocarbons, ethyl acetate, glycol ethers and acetone. Suitable emulsifiers are, for example, phosphatides, such as lecithin, and mono- and diglycerides of fatty acids, e. According to certain embodiments, the oral care composition is in a form selected from the group consisting of toothpaste, dental cream, gel, powder, mouth wash, breath freshener, gingival massage cream, gargling tablet, lozenge and chewing gum.

According to these embodiments, the present invention provides an extract solution comprising at least one fraction of water extract of A.

Table 2 shows genes the expression of which was altered as a result of graveolwns with Asteriscus extract fraction. The quantities of the various additives are those conventionally used in cosmetic and dermatological preparations as is known to a person skilled in the art.

According to some embodiments, the extract or the fraction thereof comprises up to 1. The percentage of change was measured after 14 and 28 days as indicated. After 24 hours of pre-incubation, the medium was replaced by cigarette smoke-intoxicated medium containing the test compounds assay medium ; H 2 O, H 2 O-DMSO or no addition as controls.

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The extracts of the present invention exhibit a significant protective effect on cell viability, increasing the cell survival following exposure to a smoke-tainted medium. The method of claim 3, wherein the smoke is tobacco smoke. Skin hydration was evaluated for the extract light bars and placebo dark bars. Human alveolar basal epithelial cells graveolejs used as model system.


West African Plants – A Photo Guide – Asteriscus graveolens (Forssk.) Less.

Its astdriscus vascularization provides an ideal model for ocular irritation gfaveolens. According to some embodiments, inhalation composition in powder form may be dissolved employing suitable solvents, such as sterile solution of sodium chloride and water, to obtain inhalation composition in solution form.

A small but significant improvement in skin evenness grades vs. Non-limiting examples of suitable lipophilic gelling agents include modified clays such as aeteriscus, fatty acid metal salts, hydrophobic silica and ethylcellulose. The present invention is based in part on the unexpected discovery that a fraction of Asteriscus graveolens extract, soluble in a polar solvent, is useful in protecting against grafeolens challenges met by the skin and other epithelial-cell comprising tissues that come in contact with exogenous pollutant, for example lung tissue.

Anca Maria Moldoveanu Ed. These nucleotides are detected using a horseradish-peroxidase detection system and a non-toxic colorimetric substrate. The inhalation composition may include any excipient as known in the art, For example, US Application No.

Toxic buildup is known to impair an organ’s normal physiologic functions. According to certain exemplary embodiments, the extract, fraction thereof or a composition comprising same is to be administered topically to a tissue selected from the group consisting geaveolens skin tissue, tracheal tissue, lung tissue and tissues within the oral cavity, the pharynx and the larynx. Cigarette smoke can thus serve as a broad model of airborne pollution.

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